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With decreasing profit margins, increasing cost pressures, growing regulatory compliance concerns, mounting pressure from generic drugs and increasing anxiety about the future of healthcare reimbursement, pharmaceutical manufacturers are now forced to re-examine and re-assess the way they have been doing things. In order to sustain profitability, these companies are looking to reduce waste (of all kinds), improve efficiency and increase productivity. Many of them are taking a closer look at lean manufacturing as a way to achieve these goals. Lean biomanufacturing re-visits lean principles and then applies them sympathetically - in a highly practical approach - to the specific needs of pharmaceutical processes, which present significantly different challenges to more mainstream manufacturing processes. A major goal of the book is to highlight those problems and issues that appear more specific or unique to biopharmaceutical manufacturing situations and to provide some insights into what challenges are the important ones to solve and what techniques, tools and mechanisms to employ to be successful.

Following an introduction to lean biomanufacturing, the book goes on to discuss lean technologies and methods applied in biomanufacturing. Later chapters cover the creation and implementation of the Transition Plan, issues facing the biopharmaceutical industry, creating a lean approach towards biopharmaceutical processes and the contribution of simulation models in developing these processes. The final chapter covers examples of new technology innovations which help facilitate lean biomanufacturing.

• A focus on the issues associated with the application of lean principles to biomanufacturing
• Practical examples of factors which can affect biopharmaceutical processes
• Coverage of key factors which require integration to run an efficient biopharmaceutical process

• Sales Rank: #1526559 in Books
• Published on: 2013-11-14
• Original language: English
• Number of items: 1
• Dimensions: 9.21" h x .88" w x 6.14" l, .0 pounds
• Binding: Hardcover
• 384 pages

About the Author
Nigel J. Smart PhD is a 30 year veteran of the biotechnology industry who has spent his career involved in developing and manufacturing numerous recombinant protein, monoclonal antibody and vaccine products. He holds a BSc from the University of Leicester, and an MSc and PhD in Fermentation Technology/Biochemical Engineeringfrom the University of Manchester. His career has spanned academia, Big Pharma and progressive biotechnology companies involved in cutting-edge biopharmaceutical products. For the last eleven years he has been a much sought-after consultant solving operational problems and compliance related issues to the pharmaceutical and biopharmaceutical industry. This has also included advising the US government on manufacturing strategies to produce a variety of biological countermeasures for the biodefense program. As Managing Partner of Smart Consulting Group, Dr Smart is now a proponent of lean approaches to biopharmaceutical manufacturing processes and leads the company’s business team in this area.

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• Published on: 1974
• Binding: Unknown Binding

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Sinfest is BACK, and better than ever! Viva la Resistance features over a year and a half of never-before-collected strips from the webcomic phenomenon that's "head-and-shoulders above the rest [… and] superior to most print comic strips, too," (R.C. Harvey). What other series has had the chutzpah to make characters out of God, the Devil, Jesus, Buddha, Barack Obama, Sarah Palin, and corrupt Wall Street CEOs? As the Onion's A.V. Club remarked, Tatsuya Ishida's Sinfest is "irreverent and playful… [crossing] lines that few cartoonists would dare toe."

Widely acclaimed for both style and content, Sinfest is a frequent entry in critics' "Best Comics of the Year" lists (Comics Journal, MTV, Comics Reporter, Comics Worth Reading) and just hit its tenth year of serialization. Don't miss it!

• Sales Rank: #1067724 in Books
• Published on: 2011-01-04
• Released on: 2011-01-04
• Original language: English
• Number of items: 1
• Dimensions: 9.80" h x .60" w x 8.30" l, 1.16 pounds
• Binding: Paperback
• 216 pages

Most helpful customer reviews

26 of 27 people found the following review helpful.
Way. Too. Funny!
By Ilse von Hoffmanstahl
I stumbled onto Sinfest at the Keenspot site while browsing the offerings there, and immediately had to go back and read from the first strip. Sinfest is a guilty pleasure; you know it's naughty, but you can't help it.
I like that Mr. Ishida gives God equal billing, and the characters interact with God (and the Devil) in a way that I think a lot of people do--asking frank questions, trying to understand the way things go in life.
The art style is crisp and the subject matter is wickedly sharp--not to mention very, very funny.

18 of 20 people found the following review helpful.
The best unsyndicated comic strip
By A Customer
Sinfest is quite frankly, THE best unsyndicated comic strip out there. As another reviewer said, it's risque nature-while making it frank and funnier-works against it when it comes to getting syndication. But the quality of the comic strip is superb, surpassing a good deal of the syndicated strips.
Ishida's huge back-archive of comics is also delightful as it allows newcomers access to so many good comics. So buy this book and support this strip's continuation.

17 of 19 people found the following review helpful.
The Resistance
By Ben Argyle
Tatsuya Ishida, as others have remarked, is god. Maybe not The God, but A god. At least when it comes to comic artistry. His drawings are mature, clear and unlike many other online cartoonists nowadays he doesn't reuse the same cell over and over again.
His characters (while unbelievable as most are) involve you, and frankly you want Monique to do the dirty with Slick, purely for the comedy value. Tatsuya's forays into other areas (such as calligraphy) rock most aggregiously and he should do more of them. Now.
I've been reading and loving Tatsuya's work since a month after he went online and can't believe he still hasn't been picked up for publication in a newspaper or magazine. As a previous reviewer noted, he doesn't cater to the PG or U market, but what he writes is funny, witty and has been more than enough to leave me laughing for minutes after I've finished the day's strip.
Buy this book. And ask him to publish the next couple of years, right now.

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• Published on: 1998
• Binding: Paperback

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• Sales Rank: #11873731 in Books
• Published on: 2004
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What is the role and meaning of probability in physical theory, in particular in two of the most successful theories of our age, quantum physics and statistical mechanics? Laws once conceived as universal and deterministic, such as Newton‘s laws of motion, or the second law of thermodynamics, are replaced in these theories by inherently probabilistic laws. This collection of essays by some of the world‘s foremost experts presents an in-depth analysis of the meaning of probability in contemporary physics. Among the questions addressed are: How are probabilities defined? Are they objective or subjective? What is their  explanatory value? What are the differences between quantum and classical probabilities? The result is an informative and thought-provoking book for the scientifically inquisitive. 

• Sales Rank: #4824492 in Books
• Published on: 2012-03-13
• Original language: English
• Number of items: 1
• Dimensions: 9.25" h x 6.25" w x .50" l, 1.30 pounds
• Binding: Hardcover
• 324 pages

Review

From the reviews:

“This collection of 18 essays looks at the long-debated role of probability in physics. … This collection leaves readers appreciating the complexity of the philosophical problem. Physicists and philosophers of science should both find this interesting. Summing Up: Recommended. Graduate students, researchers/faculty, and professionals.” (E. Kincanon, Choice, Vol. 50 (1), September, 2012)

From the Back Cover

What is the role and meaning of probability in physical theory, in particular in two of the most successful theories of our age, quantum physics and statistical mechanics? Laws once conceived as universal and deterministic, such as Newton‘s laws of motion, or the second law of thermodynamics, are replaced in these theories by inherently probabilistic laws. This collection of essays by some of the world‘s foremost experts presents an in-depth analysis of the meaning of probability in contemporary physics. Among the questions addressed are: How are probabilities defined? Are they objective or subjective? What is their  explanatory value? What are the differences between quantum and classical probabilities? The result is an informative and thought-provoking book for the scientifically inquisitive. 

About the Author

Yemima Ben-Menahem is professor of philosophy at The Hebrew University of Jerusalem. She has written extensively on the philosophy of science and is author of Conventionalism (Cambridge University Press).

 

Meir Hemmo is associate professor of philosophy at the University of Haifa. He has written extensively on the foundations of quantum mechanics and statistical mechanics and is co-author (with Orly Shenker) of The Road to Maxwell’s Demon (forthcoming in Cambridge University of Press).

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Probability in Physics (The Frontiers Collection)From Springer PDF
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Probability in Physics (The Frontiers Collection)From Springer PDF

Probability in Physics (The Frontiers Collection)From Springer PDF

Probability in Physics (The Frontiers Collection)From Springer PDF

Probability in Physics (The Frontiers Collection)From Springer PDF